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Irbesartan prevents angiotensin II binding to your AT1 receptor in tissues like vascular easy muscle and the adrenal gland. Irbesartan and its Lively metabolite bind the AT1 receptor with 8500 instances more affinity than they bind to your AT2 receptor.
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If digitalis has also been administered, hypokalemia may perhaps accentuate cardiac arrhythmias. The degree to which hydrochlorothiazide is taken out by hemodialysis hasn't been established. The oral LD50 of hydrochlorothiazide is greater than ten g/kg in both of those mice and rats.
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Irbesartan's avoidance of angiotensin II binding triggers vascular easy muscle mass arena plus rest and helps prevent the secretion of aldosterone, reducing blood pressure.
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